Dynamics of membrane tethers reveal novel aspects of cytoskeleton-membrane interactions in axons.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/6249

Title:	Dynamics of membrane tethers reveal novel aspects of cytoskeleton-membrane interactions in axons.
Authors:	Datar, Anagha S. Bornschogol, Thomas Bassereau, Patricia Prost, Jacques Pullarkat, Pramod A.
Keywords:	12months
Issue Date:	Feb-2015
Publisher:	Biophysical Society
Citation:	Biophysical Journal, 2015, Vol.108, p 489-497
Abstract:	Mechanical properties of cell membranes are known to be significantly influenced by the underlying cortical cytoskeleton. The technique of pulling membrane tethers from cells is one of the most effective ways of studying the membrane mechanics and the membrane-cortex interaction. In this article, we show that axon membranes make an interesting system to explore as they exhibit both free membrane-like behavior where the tether-membrane junction is movable on the surface of the axons (unlike many other cell membranes) as well as cell-like behavior where there are transient and spontaneous eruptions in the tether force that vanish when F-actin is depolymerized. We analyze the passive and spontaneous responses of axonal membrane tethers and propose theoretical models to explain the observed behavior
Description:	Restricted Access.
URI:	http://hdl.handle.net/2289/6249
ISSN:	0006-3495
Alternative Location:	http://dx.doi.org/10.1016/j.bpj.2014.11.3480
Copyright:	Restricted Access.
Appears in Collections:	Research Papers (SCM)

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