DSpace
 

RRI Digital Repository >
06. Soft Condensed Matter >
Research Papers (SCM) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/4172

Title: Spatiotemporal regulation of chemical reactions by active cytoskeletal remodeling
Authors: Chaudhuri, Abhishek
Bhattacharya, Bhaswati
Gowrishankar, Kripa
Mayor, Satyajit
Rao, Madan
Keywords: active hydrodynamics
signal transduction
Issue Date: Sep-2011
Publisher: National Academy of Sciences of the United States of America
Citation: Proceedings of the National Academy of Sciences of the United States of America, 2011, Vol.108, p14825
Abstract: Efficient and reproducible construction of signaling and sorting complexes, both on the surface and within the living cell, is contingent on local regulation of biochemical reactions by the cellular milieu. We propose that in many cases this spatiotemporal regulation can be mediated by interaction with components of the dynamic cytoskeleton.We show how the interplay between active contractility and remodeling of the cytoskeleton can result in transient focusing of passive molecules to form clusters, leading to a dramatic increase in the reaction efficiency and output levels. The dynamic cytoskeletal elements that drive focusing behave as quasienzymes catalyzing the chemical reaction. These ideas are directly applicable to the cortical actin-dependent clustering of cell surface proteins such as lipid-tethered GPI-anchored proteins, Ras proteins, as well as many proteins that have domains that confer the ability to interact with the actin cytoskeleton. In general such cytoskeletal driven clustering of proteins could be a cellular mechanism to spatiotemporally regulate and amplify local chemical reaction rates in a variety of contexts such as signaling, transcription, sorting, and endocytosis.
Description: Restricted Access.
URI: http://hdl.handle.net/2289/4172
ISSN: 1091-6490 (online)
Alternative Location: http://dx.doi.org/10.1073/pnas.1100007108
Copyright: 2011 National Academy of Sciences of the United States of America
Appears in Collections:Research Papers (SCM)

Files in This Item:

File Description SizeFormat
2011_PNAS, Vol.108_p14825.pdfRestricted access479.9 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

    RRI Library DSpace