1. RRI Digital Repository
  2. 06. Soft Condensed Matter
  3. Research Papers (SCM)
Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/4172
Full metadata record
DC FieldValueLanguage
dc.contributor.authorChaudhuri, Abhishek-
dc.contributor.authorBhattacharya, Bhaswati-
dc.contributor.authorGowrishankar, Kripa-
dc.contributor.authorMayor, Satyajit-
dc.contributor.authorRao, Madan-
dc.date.accessioned2011-09-30T04:13:30Z-
dc.date.available2011-09-30T04:13:30Z-
dc.date.issued2011-09-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2011, Vol.108, p14825en
dc.identifier.issn1091-6490 (online)-
dc.identifier.urihttp://hdl.handle.net/2289/4172-
dc.descriptionRestricted Access.en
dc.description.abstractEfficient and reproducible construction of signaling and sorting complexes, both on the surface and within the living cell, is contingent on local regulation of biochemical reactions by the cellular milieu. We propose that in many cases this spatiotemporal regulation can be mediated by interaction with components of the dynamic cytoskeleton.We show how the interplay between active contractility and remodeling of the cytoskeleton can result in transient focusing of passive molecules to form clusters, leading to a dramatic increase in the reaction efficiency and output levels. The dynamic cytoskeletal elements that drive focusing behave as quasienzymes catalyzing the chemical reaction. These ideas are directly applicable to the cortical actin-dependent clustering of cell surface proteins such as lipid-tethered GPI-anchored proteins, Ras proteins, as well as many proteins that have domains that confer the ability to interact with the actin cytoskeleton. In general such cytoskeletal driven clustering of proteins could be a cellular mechanism to spatiotemporally regulate and amplify local chemical reaction rates in a variety of contexts such as signaling, transcription, sorting, and endocytosis.en
dc.language.isoenen
dc.publisherNational Academy of Sciences of the United States of Americaen
dc.relation.urihttp://dx.doi.org/10.1073/pnas.1100007108en
dc.rights2011 National Academy of Sciences of the United States of Americaen
dc.subjectactive hydrodynamicsen
dc.subjectsignal transductionen
dc.titleSpatiotemporal regulation of chemical reactions by active cytoskeletal remodelingen
dc.typeArticleen
Appears in Collections:Research Papers (SCM)

Files in This Item:
File Description SizeFormat 
2011_PNAS, Vol.108_p14825.pdf
  Restricted Access		Restricted access479.9 kBAdobe PDFView/Open Request a copy
Show simple item record


Items in RRI Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.