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Title: Chirality-Induced Budding: A Raft-Mediated Mechanism for Endocytosis and Morphology of Caveolae?
Authors: Sarasij, R.C.
Mayor, Satyajit
Rao, Madan
Issue Date: May-2007
Publisher: Biophysical Society
Citation: Biophysical Journal, 2007, V92, p3140-3158.
Abstract: The formation of transport carriers (spherical vesicles and tubules) involves membrane budding, growth, and ultimately fission. We propose a mechanism of membrane budding, wherein the tilt and chirality of constituent molecules, confined to a patch of area A, induces buds of ~50–100 nm that are comparable to vesicles involved in endocytosis. Because such chiral and tilted lipid molecules are likely to exist in "rafts", we suggest the involvement of this mechanism in generating membrane buds in the clathrin and dynamin-independent, raft-component mediated endocytosis of glycosylphosphatidylinositol-anchored proteins. We argue that caveolae, permanent cell surface structures with characteristic morphology and enriched in raft constituents, are also likely to be formed by this mechanism. Thus, molecular chirality and tilt, and its expression over large spatial scales may be a common organizing principle in membrane budding of transport carriers.
Description: Restricted Access. The article will be made open-access at the journal site (alternative location) after 12 months.
ISSN: E-ISSN: 1542-0086
P-ISSN: 0006-3495
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Copyright: 2007 Biophysical Society
Appears in Collections:Research Papers (TP)

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