Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/3339
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSarasij, R.C.-
dc.contributor.authorMayor, Satyajit-
dc.contributor.authorRao, Madan-
dc.date.accessioned2007-10-05T09:54:05Z-
dc.date.available2007-10-05T09:54:05Z-
dc.date.issued2007-05-
dc.identifier.citationBiophysical Journal, 2007, V92, p3140-3158.en
dc.identifier.issnE-ISSN: 1542-0086-
dc.identifier.issnP-ISSN: 0006-3495-
dc.identifier.urihttp://hdl.handle.net/2289/3339-
dc.descriptionRestricted Access. The article will be made open-access at the journal site (alternative location) after 12 months.en
dc.description.abstractThe formation of transport carriers (spherical vesicles and tubules) involves membrane budding, growth, and ultimately fission. We propose a mechanism of membrane budding, wherein the tilt and chirality of constituent molecules, confined to a patch of area A, induces buds of ~50–100 nm that are comparable to vesicles involved in endocytosis. Because such chiral and tilted lipid molecules are likely to exist in "rafts", we suggest the involvement of this mechanism in generating membrane buds in the clathrin and dynamin-independent, raft-component mediated endocytosis of glycosylphosphatidylinositol-anchored proteins. We argue that caveolae, permanent cell surface structures with characteristic morphology and enriched in raft constituents, are also likely to be formed by this mechanism. Thus, molecular chirality and tilt, and its expression over large spatial scales may be a common organizing principle in membrane budding of transport carriers.en
dc.format.extent577299 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherBiophysical Societyen
dc.relation.urihttp://dx.doi.org/10.1529/biophysj.106.085662en
dc.rights2007 Biophysical Societyen
dc.titleChirality-Induced Budding: A Raft-Mediated Mechanism for Endocytosis and Morphology of Caveolae?en
dc.typeArticleen
Appears in Collections:Research Papers (TP)

Files in This Item:
File Description SizeFormat 
2007 BJ V92 p3140.pdf
  Restricted Access
Restricted Access563.77 kBAdobe PDFView/Open Request a copy


Items in RRI Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.