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http://hdl.handle.net/2289/8110| Title: | Closed-loop fluid–fluid immiscibility in binary lipid–sterol membranes |
| Authors: | Kamal, Md. Arif Polley, Anirban Shabeeb, P. K. Raghunathan, V. A. |
| Issue Date: | 14-Jun-2023 |
| Publisher: | The National Academy of Sciences |
| Citation: | Proceedings of the National Academy of Sciences, 2023, Vol. 120, e2216002120 |
| Abstract: | We present two binary lipid–sterol membrane systems that exhibit fluid–fluid coexistence. Partial phase diagrams of binary mixtures of dimyristoylphosphatidylcholine with 25-hydroxyxholesterol and 27-hydroxycholesterol, determined from small-angle X-ray scattering and fluorescence microscopy studies, show closed-loop fluid–fluid immiscibility gaps, with the appearance of a single fluid phase both at higher and lower temperatures. Computer simulations suggest that this unusual phase behavior results from the ability of these oxysterol molecules to take different orientations in the membrane depending on the temperature. |
| Description: | Restricted Access. |
| URI: | http://hdl.handle.net/2289/8110 |
| ISSN: | 0027-8424 1091-6490 (Online) |
| Alternative Location: | https://doi.org/10.1073/pnas.221600212 |
| Copyright: | 2023 The Author(s) |
| Appears in Collections: | Research Papers (SCM) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2023_PNAS_2216002120.pdf Restricted Access | Restricted Access | 5.5 MB | Adobe PDF | View/Open Request a copy |
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