Closed-loop fluid–fluid immiscibility in binary lipid–sterol membranes

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/8110

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DC Field	Value	Language
dc.contributor.author	Kamal, Md. Arif	-
dc.contributor.author	Polley, Anirban	-
dc.contributor.author	Shabeeb, P. K.	-
dc.contributor.author	Raghunathan, V. A.	-
dc.date.accessioned	2023-06-22T05:45:42Z	-
dc.date.available	2023-06-22T05:45:42Z	-
dc.date.issued	2023-06-14	-
dc.identifier.citation	Proceedings of the National Academy of Sciences, 2023, Vol. 120, e2216002120	en_US
dc.identifier.issn	0027-8424	-
dc.identifier.issn	1091-6490 (Online)	-
dc.identifier.uri	http://hdl.handle.net/2289/8110	-
dc.description	Restricted Access.	en_US
dc.description.abstract	We present two binary lipid–sterol membrane systems that exhibit fluid–fluid coexistence. Partial phase diagrams of binary mixtures of dimyristoylphosphatidylcholine with 25-hydroxyxholesterol and 27-hydroxycholesterol, determined from small-angle X-ray scattering and fluorescence microscopy studies, show closed-loop fluid–fluid immiscibility gaps, with the appearance of a single fluid phase both at higher and lower temperatures. Computer simulations suggest that this unusual phase behavior results from the ability of these oxysterol molecules to take different orientations in the membrane depending on the temperature.	en_US
dc.language.iso	en	en_US
dc.publisher	The National Academy of Sciences	en_US
dc.relation.uri	https://doi.org/10.1073/pnas.221600212	en_US
dc.rights	2023 The Author(s)	en_US
dc.title	Closed-loop fluid–fluid immiscibility in binary lipid–sterol membranes	en_US
dc.type	Article	en_US
Appears in Collections:	Research Papers (SCM)

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