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Title: Theranostic lyotropic liquid crystalline nanostructures for selective breast cancer imaging and therapy
Authors: Urandur, Sandeep
Banala, Venkatesh Teja
Pratibha, R.
+7 Co-Authors
Keywords: Cancer theranostics
Lyotropic liquid crystals
Chemodynamic therapy
Optical imaging
Fenton-like reaction
Issue Date: Sep-2020
Publisher: Elsevier
Citation: Acta Biomaterialia, 2020, Vol.113, p522–540
Abstract: Herein, we report the development of theranostic lyotropic liquid crystalline nanostructures (LCN's) loaded with unique MnO nanoparticles (MNPs) for selective cancer imaging and therapy. MNPs serves as a fluorescent agent as well as a source of manganese (Mn2+) and enables localized oxidative stress under the hallmarks of cancer (acidosis, high H2O2 level). In pursuit of synergistic amplification of Mn2+ antitumor activity, betulinic acid (BA) is loaded in LCN's. In this investigation, nano-architecture of LCN's phase interface is established via SAXS, Cryo-TEM and Cryo-FESEM. Intriguing in vitro studies showed that the LCN's triggered hydroxyl radical production and exhibited greater selective cytotoxicity in cancer cells, ensuring the safety of normal cells. Significant tumor ablation is realized by the 96.5 % of tumor growth inhibition index of LCN's as compared to control group. Key insights into on-site drug release, local anti-cancer response, and tumor location are gained through precise guidance of fluorescent MNPs. In addition, comprehensive assessment of the safety, pharmacokinetics and tumor distribution behavior of LCN's is performed in vivo or ex vivo. This work emphasizes the promise of modulating tumor microenvironment with smart endogenous stimuli sensitive nano systems to achieve advanced comprehensive cancer nano-theranostics without any external stimulus.
Description: Restricted Access.
ISSN: 1742-7061
Alternative Location:
Copyright: 2020 Acta Materialia
Additional information: Supplementary information available
Appears in Collections:Research Papers (SCM)

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