Please use this identifier to cite or link to this item:
http://hdl.handle.net/2289/7522| Title: | Theranostic lyotropic liquid crystalline nanostructures for selective breast cancer imaging and therapy |
| Authors: | Urandur, Sandeep Banala, Venkatesh Teja Pratibha, R. +7 Co-Authors |
| Keywords: | Cancer theranostics Lyotropic liquid crystals Chemodynamic therapy Optical imaging Fenton-like reaction |
| Issue Date: | Sep-2020 |
| Publisher: | Elsevier |
| Citation: | Acta Biomaterialia, 2020, Vol.113, p522–540 |
| Abstract: | Herein, we report the development of theranostic lyotropic liquid crystalline nanostructures (LCN's) loaded with unique MnO nanoparticles (MNPs) for selective cancer imaging and therapy. MNPs serves as a fluorescent agent as well as a source of manganese (Mn2+) and enables localized oxidative stress under the hallmarks of cancer (acidosis, high H2O2 level). In pursuit of synergistic amplification of Mn2+ antitumor activity, betulinic acid (BA) is loaded in LCN's. In this investigation, nano-architecture of LCN's phase interface is established via SAXS, Cryo-TEM and Cryo-FESEM. Intriguing in vitro studies showed that the LCN's triggered hydroxyl radical production and exhibited greater selective cytotoxicity in cancer cells, ensuring the safety of normal cells. Significant tumor ablation is realized by the 96.5 % of tumor growth inhibition index of LCN's as compared to control group. Key insights into on-site drug release, local anti-cancer response, and tumor location are gained through precise guidance of fluorescent MNPs. In addition, comprehensive assessment of the safety, pharmacokinetics and tumor distribution behavior of LCN's is performed in vivo or ex vivo. This work emphasizes the promise of modulating tumor microenvironment with smart endogenous stimuli sensitive nano systems to achieve advanced comprehensive cancer nano-theranostics without any external stimulus. |
| Description: | Restricted Access. |
| URI: | http://hdl.handle.net/2289/7522 |
| ISSN: | 1742-7061 |
| Alternative Location: | https://doi.org/10.1016/j.actbio.2020.06.023 |
| Copyright: | 2020 Acta Materialia |
| Additional information: | Supplementary information available |
| Appears in Collections: | Research Papers (SCM) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2020_Acta biomaterialia_Vol.113_p522.pdf Restricted Access | Restricted Access | 7.16 MB | Adobe PDF | View/Open Request a copy |
| 2020_Acta biomaterialia_Vol.113_p522_Suply Info.pdf Restricted Access | Restricted Access | 1.62 MB | Adobe PDF | View/Open Request a copy |
Items in RRI Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.