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Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/7354
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dc.contributor.authorPaddillaya, Neha-
dc.contributor.authorMishra, Ashish-
dc.contributor.authorPullarkat, Pramod A.-
dc.contributor.author+3 Co-Authors-
dc.date.accessioned2019-11-18T05:58:30Z-
dc.date.available2019-11-18T05:58:30Z-
dc.date.issued2019-11-08-
dc.identifier.citationFrontiers in Cell and Developmental Biology: Cell Adhesion and Migration,2019, Vol.7, Article No.251en_US
dc.identifier.issn2296-634X (Online)-
dc.identifier.urihttp://hdl.handle.net/2289/7354-
dc.descriptionOpen Access.en_US
dc.description.abstractCells adhere to substrates through mechanosensitive focal adhesion complexes. Measurements that probe how cells detach from substrates when they experience an applied force connect molecular-scale aspects of cell adhesion with the biophysical properties of adherent cells. Such forces can be applied through shear devices that flow fluid in a controlled manner across cells. The signaling pathways associated with focal adhesions, in particular those that involve integrins and receptor tyrosine kinases, are complex, receiving mechano-chemical feedback from the sensing of substrate stiffness as well as of external forces. This article reviews the signaling processes involved in mechanosensing and mechanotransduction during cell-substrate interactions, describing the role such signaling plays in cancer metastasis. We examine some recent progress in quantifying the strength of these interactions, describing a novel fluid shear device that allows for the visualization of the cell and its sub-cellular structures under a shear flow. We also summarize related results from a biophysical model for cellular de-adhesion induced by applied forces. Quantifying cell-substrate adhesions under shear should aid in the development of mechano-diagnostic techniques for diseases in which cell-adhesion is mis-regulated, such as cancers.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.urihttps://doi.org/10.3389/fcell.2019.00251en_US
dc.rights2019 Paddillaya, Mishra, Kondaiah, Pullarkat, Menon and Gundiahen_US
dc.subjectfocal adhesionsen_US
dc.subjectstress fibersen_US
dc.subjectmechanotransductionen_US
dc.subjectshear stress and devicesen_US
dc.subjectbiophysical modelsen_US
dc.subjectadhesion strengthen_US
dc.titleBiophysics of Cell-Substrate Interactions Under Shearen_US
dc.typeArticleen_US
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