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Title: Zirconia-Supported Cu(I)-Stabilized copper oxide Mesoporous catalyst for the synthesis of Quinazolinones under ambient conditions
Authors: Parashuram, L.
Sreenivasa, S.
Akshatha, S.
Udaya Kumar, V.
Kumar, Sandeep
Issue Date: Dec-2017
Publisher: Wiley-VCH Verlag
Citation: Asian Journal of Organic Chemistry, 2017, Vol 6, 1755
Abstract: Although there are many reports on the synthesis of quinazolinones, the use of high boiling solvents and high temperature restricts their scale-up to the industrial level. The current research reveals a simple protocol for the catalytic synthesis of quinazolines in the presence of a cost-effective and reusable mesoporous ZrO2-supported Cu2O (Cu2ZrO3) catalyst. The catalyst was prepared by simple co-precipitation and characterized using techniques like XRD, TGA, BET, SEM and TEM. The catalyst was reused for five cycles without significant loss in the activity and the catalyst was truly heterogeneous. The present synthesis utilizes environmentally benign H2O2 as an oxidant. The present protocol showed good tolerance for various substituted aldehydes and good yields for quinazolinone derivatives. The method followed a simple workup procedure and no column chromatography was needed.
Description: Restricted Access.
ISSN: 2193-5815
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Copyright: 2017 Wiley-VCH Verlag
Appears in Collections:Research Papers (SCM)

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