Organelle morphogenesis by active membrane remodeling

Ramakrishnan, N.; Ipsen, John H; Rao, Madan; Sunil Kumar, P.B.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/6238

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DC Field	Value	Language
dc.contributor.author	Ramakrishnan, N.	-
dc.contributor.author	Ipsen, John H	-
dc.contributor.author	Rao, Madan	-
dc.contributor.author	Sunil Kumar, P.B.	-
dc.date.accessioned	2015-05-21T07:56:03Z	-
dc.date.available	2015-05-21T07:56:03Z	-
dc.date.issued	2015-03-28	-
dc.identifier.citation	Soft Matter, 2015, Vol. 11, p 2387-2393	en
dc.identifier.issn	1744-6848 (Online)	-
dc.identifier.issn	1744-683X	-
dc.identifier.uri	http://hdl.handle.net/2289/6238	-
dc.description	Restricted Access.	en
dc.description.abstract	Intracellular organelles are subject to a steady flux of lipids and proteins through active, energy consuming transport processes. Active fission and fusion are promoted by GTPases, e.g., Arf–Coatamer and the Rab–Snare complexes, which both sense and generate local membrane curvature. Here we investigate, through Dynamical Triangulation Monte Carlo simulations, the role that these active processes play in determining the morphology and composition segregation in closed membranes. We find that the steady state shapes obtained as a result of such active processes, bear a striking resemblance to the ramified morphologies of organelles in vivo, pointing to the relevance of nonequilibrium fission–fusion in organelle morphogenesis	en
dc.language.iso	en	en
dc.publisher	Royal Society of Chemistry	en
dc.relation.uri	http://arxiv.org/abs/1403.0796	en
dc.relation.uri	http://dx.doi.org/10.1039/C4SM02311K	en
dc.rights	2015 Royal Society of Chemistry	en
dc.title	Organelle morphogenesis by active membrane remodeling	en
dc.type	Article	en
Appears in Collections:	Research Papers (SCM)

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