Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH.

Basak, R.; Bandyopadhyay, Ranjini

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/5843

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DC Field	Value	Language
dc.contributor.author	Basak, R.	-
dc.contributor.author	Bandyopadhyay, Ranjini	-
dc.date.accessioned	2013-11-19T05:50:13Z	-
dc.date.available	2013-11-19T05:50:13Z	-
dc.date.issued	2013-04-02	-
dc.identifier.citation	Langmuir, 2013, Vol 29, p4350-4356	en
dc.identifier.issn	0743-7463	-
dc.identifier.issn	1520-5827 (Online)	-
dc.identifier.uri	http://hdl.handle.net/2289/5843	-
dc.description	Restricted Access.	en
dc.description.abstract	Three drugs, ibuprofen, aspirin, and erythromycin, are encapsulated in spherical Pluronic F127 micelles. The shapes and the size distributions of the micelles in dilute, aqueous solutions, with and without drugs, are ascertained using cryo-scanning electron microscopy and dynamic light scattering (DLS) experiments, respectively. Uptake of drugs above a threshold concentration is seen to reduce the critical micellization temperature of the solution. The mean hydrodynamic radii and polydispersities of the micelles are found to increase with decrease in temperature and in the presence of drug molecules. The hydration of the micellar core at lower temperatures is verified using fluorescence measurements. Increasing solution pH leads to the ionization of the drugs incorporated in the micellar cores. This causes rupture of the micelles and release of the drugs into the solution at the highest solution pH value of 11.36 investigated here and is studied using DLS and fluorescence spectrocopy.	en
dc.language.iso	en	en
dc.publisher	American Chemical Society	en
dc.relation.uri	http://dx.doi.org/10.1021/la304836e	en
dc.rights	2013 American Chemical Society	en
dc.title	Encapsulation of hydrophobic drugs in Pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH.	en
dc.type	Article	en
Appears in Collections:	Research Papers (TP)

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