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Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/5558
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dc.contributor.authorMishra, Mithilesh-
dc.contributor.authorHuang, Yinyi-
dc.contributor.authorSrivastava, Pragya-
dc.contributor.authorSrinivasan, Ramanujam-
dc.contributor.authorSevugan, Mayalagu-
dc.contributor.authorShlomovitz, Roie-
dc.contributor.authorGov, Nir S.-
dc.contributor.authorRao, Madan-
dc.contributor.authorBalasubramanian, Mohan-
dc.date.accessioned2013-04-24T08:50:46Z-
dc.date.available2013-04-24T08:50:46Z-
dc.date.issued2012-08-15-
dc.identifier.citationJournal of Cell Science, 2012, Vol.125, p 3850en
dc.identifier.issn0021-9533-
dc.identifier.issn1477-9137-
dc.identifier.urihttp://hdl.handle.net/2289/5558-
dc.descriptionRestricted Access.en
dc.description.abstractSuccessful cytokinesis requires proper assembly of the contractile actomyosin ring, its stable positioning on the cell surface and proper constriction. Over the years, many of the key molecular components and regulators of the assembly and positioning of the actomyosin ring have been elucidated. Here we show that cell geometry and mechanics play a crucial role in the stable positioning and uniform constriction of the contractile ring. Contractile rings that assemble in locally spherical regions of cells are unstable and slip towards the poles. By contrast, actomyosin rings that assemble on locally cylindrical portions of the cell under the same conditions do not slip, but uniformly constrict the cell surface. The stability of the rings and the dynamics of ring slippage can be described by a simple mechanical model. Using fluorescence imaging, we verify some of the quantitative predictions of the model. Our study reveals an intimate interplay between geometry and actomyosin dynamics, which are likely to apply in a variety of cellular contexts.en
dc.language.isoenen
dc.publisherCompany of Biologists Ltden
dc.relation.urihttp://dx.doi.org/10.1242/jcs.103788en
dc.rights2012 Company of Biologistsen
dc.subjectActinomysin ringen
dc.subjectCell geometryen
dc.subjectCell divisionen
dc.titleCylindrical cellular geometry ensures fidelity of division site placement in fission yeasten
dc.typeArticleen
Appears in Collections:Research Papers (TP)

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