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Title: Modulated phases of lipid membranes induced by sterol derivatives
Authors: Kamal, Md. Arif
Pal, Antara
Raghunathan, V.A.
Issue Date: 7-Nov-2012
Publisher: Royal Society of Chemistry
Citation: Soft Matter, 2012, Vol.8, p11600-11603
Abstract: We have studied the effect of two secosteroids, namely cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2), on the structure and phase behavior of dipalmitoyl phosphatidylcholine (DPPC) membranes using X-ray diffraction. Temperature–composition phase diagrams of both the systems have been determined from diffraction data of aligned multilayers at 98% relative humidity. The two phase diagrams are found to be almost identical, with the appearance of four distinct modulated phases as a function of secosteroid concentration below the main-transition of the lipid. Three of these phases are characterized by periodic height modulation of the bilayers, whereas the one that occurs at high secosteroid concentrations has a periodic thickness modulation. As far as we know, this is the first report on the thickness modulated phase of lipid bilayers.
Description: Restricted Access.
ISSN: 1744-683X
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Copyright: 2012 Royal Society of Chemistry
Appears in Collections:Research Papers (SCM)

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