Modulated phases of phospholipid bilayers induced by tocopherols

Kamal, Md. Arif; Raghunathan, V.A.

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/5336

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DC Field	Value	Language
dc.contributor.author	Kamal, Md. Arif	-
dc.contributor.author	Raghunathan, V.A.	-
dc.date.accessioned	2012-11-30T09:30:21Z	-
dc.date.available	2012-11-30T09:30:21Z	-
dc.date.issued	2012-11	-
dc.identifier.citation	Biochimica et Biophysica Acta , 2012, Vol. 1818, p2486	en
dc.identifier.issn	0006-3002	-
dc.identifier.uri	http://hdl.handle.net/2289/5336	-
dc.description	Restricted Access.	en
dc.description.abstract	The influence of α-, γ‐ and δ-tocopherols on the structure and phase behavior of dipalmitoyl phosphatidylcholine (DPPC) bilayers has been determined from X-ray diffraction studies on oriented multilayers. In all the three cases the main-transition temperature (Tm) of DPPC was found to decrease with increasing tocopherol concentration up to around 25 mol%. Beyond this the main transition is suppressed in the case of γ‐tocopherol, whereas Tm becomes insensitive to composition in the other two cases. The pre-transition is found to be suppressed over a narrow tocopherol concentration range between 7.5 and 10 mol% in DPPC‐γ-tocopherol and DPPC-δ‐tocopherol bilayers, and the ripple phase occurs down to the lowest temperature studied. In all the three cases a modulated phase is observed above a tocopherol concentration of about 10 mol%, which is similar to the Pβ phase reported in DPPC–cholesterol bilayers. This phase is found to occur even in excess water conditions at lower tocopherol concentrations, and consists of bilayers with periodic height modulation. These results indicate the ability of tocopherols to induce local curvature in membranes, which could be important for some of their biological functions	en
dc.language.iso	en	en
dc.publisher	Elsevier B.V.	en
dc.relation.uri	http://dx.doi.org/10.1016/j.bbamem.2012.06.016	en
dc.rights	2012 Elsevier B.V.	en
dc.subject	Phospholipid bilayer	en
dc.subject	Tocopherol	en
dc.subject	X-ray diffraction	en
dc.title	Modulated phases of phospholipid bilayers induced by tocopherols	en
dc.type	Article	en
Appears in Collections:	Research Papers (SCM)

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