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Title: Drag force as a tool to test the active mechanical response of PC12 neurites
Authors: Bernal, Roberto
Melo, Francisco
Pullarkat, Pramod A.
Issue Date: Feb-2010
Publisher: Elsevier for Biophysical Society
Citation: Biophysical Journal, 2010, Vol.98, p515
Abstract: We investigate the mechanical response of PC12 neurites subjected to a drag force imposed by a laminar flow perpendicular to the neurite axis. The curvature of the catenary shape acquired by an initially straight neurite under the action of the drag force provides information on both elongation and tension of the neurite. This method allows us to measure the rest tension and viscoelastic parameters of PC12 neurites and active behavior of neurites. Measurement of oscillations in the strain rate of neurites at constant flow rate provides insight on the response of molecular motors and additional support for the presence of a negative strain-rate sensitivity region in the global mechanical response of PC12 neurites.
Description: Restricted Access. Articles older than 12 months are open to all at the journal site (alternative location)
ISSN: 1542-0086 (Online)
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Copyright: 2010 Biophysical Society
Appears in Collections:Research Papers (SCM)

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