Title:	Pressure studies on two hydrated phospholipids - 1,2-dimyristoyl-phosphatidylcholine and 1,2-dipalmitoyl-phosphatidylcholine
Authors:	Krishna Prasad, S. Shashidhar, R. Gaber, B.P. Chandrasekhar, S.
Keywords:	phase diagrams; pressure studies; dimyristoyl phosphatidylcholine; dipalmitoyl phosphatidylcholine
Issue Date:	Apr-1987
Publisher:	Elsevier Science Ireland Ltd.
Citation:	Chemistry and Physics of Lipids, 1987, Vol.143, p227-235
Abstract:	We present results of studies on the effect of pressure on phase transitions in 1,2-dimyristoyl-phosphatidylcholine (DMPC) and 1,2-dipalmitoyl-phosphathatidylcholine (DPPC) dispersed in excess water. The P-T diagram of hydrated DMPC shows a Gel III-Gel II-Gel I triple point at 3.5 kbar, 41°C, the Gel III phase being obtained by annealing the sample at high pressure for several hours. In the case of DPPC, a pressure induced phase (X) appears between the Gel II and Gel I phases at not, vert, similar0.93 kbar. With increasing pressure the temperature range of the X phase increases at the expense of that of the Gel I phase until finally at 2.87 kbar, the latter is completely suppressed. The P-T diagram of water-rich DPPC thus has 2 triple points, the Gel II-X-Gel I triple point at 0.93 kbar, 42.5°C and the X-gel I-liquid crystal triple point at 2.87 kbar, 98.5°C. A pressure induced Gel III-Gel II transition is also observed in DPPC in the pressure range of 1.7–3 kbar.
Description:	Restricted Access.
URI:	http://hdl.handle.net/2289/2766
ISSN:	0009-3084
Alternative Location:	http://dx.doi.org/10.1016/0009-3084(87)90010-7
Copyright:	1987 Elsevier B.V.
Appears in Collections:	Research Papers (SCM)

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