Please use this identifier to cite or link to this item:
Title: Spontaneously formed unilamellar vesicles with path-dependent size distribution
Authors: Nieh, M.P.
Raghunathan, V.A.
Kline, Steve R.
Harroun, T.A.
Huang, Chien-Yueh
Pencer, J.
Katsaras, J.
Issue Date: 17-Jun-2005
Publisher: American Chemical Society
Citation: Langmuir, 2005, Vol. 21, p6656-6661
Abstract: We observe the spontaneous formation of path-dependent monodisperse and polydisperse phospholipid unilamellar vesicles (ULV) from two different equilibrium morphologies specifically, disklike micelles and extended lamellae, respectively. On heating beyond a temperature Tc, low temperature disklike micelles, or so-called bicelles, transform into lamellae. Dilution of the lamellar phase, at a fixed temperature, results in a complete unbinding transition and the formation of polydisperse ULV, demonstrating the instability of the lamellar phase. On the other hand, heating of a dilute bicellar phase above Tc results in monodisperse ULV, which on cooling revert back to bicelles for lipid concentrations 0.5 wt % and transform into oblate ellipsoids for = 0.1 wt %, a morphology not previously seen in "bicellar" lipid mixtures. Monodisperse ULV reform on heating of the oblate ellipsoids.
Description: Restricted Access.
ISSN: 0743-7463
Alternative Location:
Copyright: 2005 American Chemical Society
Appears in Collections:Research Papers (SCM)

Files in This Item:
File Description SizeFormat 
2005 Langmuir V21 p6656-6661.pdf
  Restricted Access
Restricted Access313.83 kBAdobe PDFView/Open Request a copy

Items in RRI Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.