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Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/8115
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dc.contributor.authorAdam, Shibil-
dc.contributor.authorMohanan, Akhil-
dc.contributor.authorBakshi, Swarnadeep-
dc.contributor.authorGhadai, Abhishek-
dc.contributor.authorMajumdar, Sayantan-
dc.date.accessioned2023-07-20T06:23:08Z-
dc.date.available2023-07-20T06:23:08Z-
dc.date.issued2023-07-01-
dc.identifier.citationColloids and Surfaces B: Biointerfaces, 2023, Vol 227, p113380en_US
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/2289/8115-
dc.descriptionRestricted Access.en_US
dc.description.abstractCollagen is the most abundant protein in the mammalian extracellular matrix. In-vitro collagen-based materials with specific mechanical properties are important for various bio-medical and tissue-engineering applications. Here, we study the reversible mechanical switching behaviour of a bio-compatible composite formed by collagen networks seeded with thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) microgel particles, by exploiting the swelling/de-swelling of the particles across the lower critical solution temperature (LCST). Interestingly, we find that the shear modulus of the system reversibly enhances whenever the diameter of the microgel particles is changed from that corresponding to the polymerization temperature of the composite, irrespective of swelling or, de-swelling. However, the degree of such enhancement significantly depends on the temperature-dependent collagen network architecture quantified by the mesh size of the network. Furthermore, confocal imaging of the composite during the temperature switching reveals that the reversible clustering of microgel particles above LCST plays a crucial role in the observed switching response.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urihttps://doi.org/10.1016/j.colsurfb.2023.113380en_US
dc.rights2023 Elsevier B.V.en_US
dc.subjectBiopolymer compositesen_US
dc.subjectRheologyen_US
dc.subjectNetwork architectureen_US
dc.subjectTissue engineeringen_US
dc.titleNetwork architecture dependent mechanical response in temperature responsive collagen-PNIPAM compositesen_US
dc.typeArticleen_US
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