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http://hdl.handle.net/2289/7822Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Chowdhury, Anindya | - |
| dc.contributor.author | Sasidharan, Sreeja | - |
| dc.contributor.author | Xavier, Pinchu | - |
| dc.contributor.author | Viswanath, P. | - |
| dc.contributor.author | Raghunathan, V.A. | - |
| dc.date.accessioned | 2021-09-21T04:27:34Z | - |
| dc.date.available | 2021-09-21T04:27:34Z | - |
| dc.date.issued | 2021-11 | - |
| dc.identifier.citation | Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021, Vol. 1863, p183695 | en_US |
| dc.identifier.issn | 0006-3002 | - |
| dc.identifier.uri | http://hdl.handle.net/2289/7822 | - |
| dc.description | Restricted Access. | en_US |
| dc.description.abstract | We have studied the effect of acidic pH on the phase behavior of the zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) using differential scanning calorimetry and x-ray scattering. Dispersions of DMPC in HCl solutions of pH = 4 and 3 behave identical to dispersions in water. The main transition temperature increases sharply and the pre-transition disappears at lower pH. An untilted gel phase is observed at pH = 2 and 1, in contrast to the tilted gel phase found at higher pH. The relatively large periodicity of the untilted gel phase, in comparison to that of the tilted gel phase occurring near neutral pH, clearly demonstrates the simultaneous charging and dehydration of the headgroups as the pH approaches the pK of the phosphate group. Headgroup dehydration at low pH also leads to the formation of DMPC crystallites and the inverted hexagonal phase at low and high temperatures, respectively, after a few days of incubation. These results show the significant effect of acidic pH on the phase behavior of zwitterionic lipids. | en_US |
| dc.language.iso | en | en_US |
| dc.relation.uri | https://doi.org/10.1016/j.bbamem.2021.183695 | en_US |
| dc.rights | 2021 Elsevier B.V. | en_US |
| dc.title | Effect of pH on the phase behavior of DMPC bilayers | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Research Papers (SCM) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2021_-biomembrane_Vol.1863_p183695.pdf Restricted Access | Restricted Access | 2.34 MB | Adobe PDF | View/Open Request a copy |
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