Modulated phases of lipid membranes induced by sterol derivatives

Please use this identifier to cite or link to this item: http://hdl.handle.net/2289/5474

Title:	Modulated phases of lipid membranes induced by sterol derivatives
Authors:	Kamal, Md. Arif Pal, Antara Raghunathan, V.A.
Issue Date:	7-Nov-2012
Publisher:	Royal Society of Chemistry
Citation:	Soft Matter, 2012, Vol.8, p11600-11603
Abstract:	We have studied the effect of two secosteroids, namely cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2), on the structure and phase behavior of dipalmitoyl phosphatidylcholine (DPPC) membranes using X-ray diffraction. Temperature–composition phase diagrams of both the systems have been determined from diffraction data of aligned multilayers at 98% relative humidity. The two phase diagrams are found to be almost identical, with the appearance of four distinct modulated phases as a function of secosteroid concentration below the main-transition of the lipid. Three of these phases are characterized by periodic height modulation of the bilayers, whereas the one that occurs at high secosteroid concentrations has a periodic thickness modulation. As far as we know, this is the first report on the thickness modulated phase of lipid bilayers.
Description:	Restricted Access.
URI:	http://hdl.handle.net/2289/5474
ISSN:	1744-683X 1744-6848(Online)
Alternative Location:	http://dx.doi.org/10.1039/C2SM26601F
Copyright:	2012 Royal Society of Chemistry
Appears in Collections:	Research Papers (SCM)

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