Title:	Spontaneously formed unilamellar vesicles with path-dependent size distribution
Authors:	Nieh, M.P. Raghunathan, V.A. Kline, Steve R. Harroun, T.A. Huang, Chien-Yueh Pencer, J. Katsaras, J.
Issue Date:	17-Jun-2005
Publisher:	American Chemical Society
Citation:	Langmuir, 2005, Vol. 21, p6656-6661
Abstract:	We observe the spontaneous formation of path-dependent monodisperse and polydisperse phospholipid unilamellar vesicles (ULV) from two different equilibrium morphologies specifically, disklike micelles and extended lamellae, respectively. On heating beyond a temperature Tc, low temperature disklike micelles, or so-called bicelles, transform into lamellae. Dilution of the lamellar phase, at a fixed temperature, results in a complete unbinding transition and the formation of polydisperse ULV, demonstrating the instability of the lamellar phase. On the other hand, heating of a dilute bicellar phase above Tc results in monodisperse ULV, which on cooling revert back to bicelles for lipid concentrations 0.5 wt % and transform into oblate ellipsoids for = 0.1 wt %, a morphology not previously seen in "bicellar" lipid mixtures. Monodisperse ULV reform on heating of the oblate ellipsoids.
Description:	Restricted Access.
URI:	http://hdl.handle.net/2289/2264
ISSN:	0743-7463
Alternative Location:	http://dx.doi.org/10.1021/la0508994
Copyright:	2005 American Chemical Society
Appears in Collections:	Research Papers (SCM)

Items in RRI Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated.