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Title: Understanding Physical Mechanisms in Chromatin Folding
Authors: Maheshwaram, Sumanth Kumar
Thesis Advisor: Soni, Gautam V.
Subject: Soft condensed matter
Issue Date: 20-Jan-2023
Publisher: Raman Research Institute
Citation: Ph.D. Thesis, Jawaharlal Nehru University, New Delhi, 2023
Abstract: The mechanics of DNA, affecting its structures, control multiple biological processes such as growth, division and differentiation of a cell resulting in the development and survival of organisms. Packaging DNA inside a cell is a fundamental biophysical problem directly relevant to gene regulation. We used gel electrophoresis, AFM imaging and primarily Nanopore-based single-molecule technique to study these structural conformations. This thesis highlights our investigations on structural forms of DNA polymer and nucleosome arrays. This thesis is divided into six chapters, as summarized below.
Description: Restricted Access
Copyright: This thesis is posted here with the permission of the author. Personal use of this material is permitted. Any other use requires prior permission of the author. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
Appears in Collections:Theses (SCM)

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